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Nazolin Nasal Spray

( Oxymetazoline Hydrochloride Nasal Spray )

Oxymetazoline Hydrochloride, the active ingredient of Nazolin® nasal spray, is a sympathomimetic amine of the imidazoline class. Nazolin® is indicated for the following purposes as a nasal decongestant in allergic rhinitis, with or without the addition of topical antihistamines or sodium cromoglycate;

Manufacturer: Beximco Pharma Ltd

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Nazolin
Nasal Spray
®
Description
Oxymetazoline Hydrochloride, the active ingredient of Nazolin nasal
spray, is a sympathomimetic amine of the imidazoline class. The chemical
name of the active ingredient is 3-[(4,5-Dihydro-1H-imidazole-2yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
hydrochloride.
Indications
¤ As a nasal decongestant in allergic rhinitis, with or without the addition
of topical antihistamines or sodium cromoglycate.
¤ As a nasal decongestant in sinusitis where there is evidence of
obstruction of osteal opening to the sinuses.
¤ As nasal decongestant in otitis media where there is evidence of
obstruction of eustachian tube, especially in subacute serous otitis
media ('glue ear') and otitic barotrauma.
¤ As a decongestant in an infective rhinitis(e.g., an acute viral upper
respiratory tract infection). Where there is a secondary bacterial
infection, there is no evidence of benefit.
Dosage and Administration
For nasal use, 2-3 sprays should be instilled into each nostril twice daily.
The nasal spray can be used with the patient in the upright position.
Sprays are generally unsuitable for young children because of the small
size of their nostril. A treatment course should not normally exceed three
to five days, and on no account should it be continued for longer than two
weeks because of the risk of developing 'rhinitis medicamentosa'.
Contraindications
¤ As a sympathomimetic, oxymetazoline should not be used in patients
being simultaneously treated with monoamine oxidase inhibitor
therapy.
¤ Narrow-angle glaucoma.
¤ The safety of use in pregnancy has not fully been established and
administration of Oxymetazoline during that time should be avoided
unless absolutely essential.
¤ Hypersensitivity to any component of this product.Precautions
The drug should be used with caution in patients suffering from coronary
artery disease, hypertension, hyperthyroidism and diabetes mellitus.
Side Effects
Used correctly (as an intranasal application), the local vasoconstriction
produced by the drug inhibits the absorption and a systemic action is
unlikely. If, however, some of the drops are swallowed, they can be
absorbed from the gastrointestinal tract and a systemic effect can be
produced. In children an overdose, if swallowed and absorbed, has been
reported to cause sedation. As Oxymetazoline is an a
adrenergic agonist,
it might be expected to produce effects similar to those of Clonidine, with
2
a short lived rise in pressure caused by a peripheral action, followed by
more prolonged hypotension and sedation as a result of inhibition of
sympathetic outflow from brain.
Overuse is associated with a more persistent rhinitis related to the
rebound phenomenon- the condition known as 'rhinitis medicamentosa'.
It is claimed that, because of its more prolonged action, Oxymetazoline
is less likely to cause rebound congestion than other decongestants.
Stinging, discomfort or a dryness locally in the nose or eye is encountered
infrequently. If the symptoms persist, the discomfort from the use of the
drops probably outweighs any advantage they may confer. Headache has
been reported, albeit infrequently, as has tachycardia.
Commercial Pack
Nazolin
Nasal Spray : Each bottle contains 200 metered doses of 0.05%
aqueous nasal preparation of Oxymetazoline Hydrochloride USP in a
®
total volume of 10 ml. Each actuation delivers 0.05 ml containing 25 mg
of Oxymetazoline Hydrochloride.

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Nazolin Nasal Spray

Nazolin Nasal Spray

( Oxymetazoline Hydrochloride Nasal Spray )

Oxymetazoline Hydrochloride, the active ingredient of Nazolin® nasal spray, is a sympathomimetic amine of the imidazoline class. Nazolin® is indicated for the following purposes as a nasal decongestant in allergic rhinitis, with or without the addition of topical antihistamines or sodium cromoglycate;

Manufacturer: Beximco Pharma Ltd

Write your review